irrigationvalley630
NIH: Using Residential History and Groundwater Modeling to Examine Drinking Water Exposure and Breast Cancer
June 2, 2016
inside-flint-pipes
NIH: Use of a Cumulative Exposure Index to Estimate the Impact of Tap Water Lead Concentration on Blood Lead Levels in 1- to 5-Year-Old Children (Montréal, Canada)
June 2, 2016
Show all

NIH: Childhood Brain Tumors, Residential Insecticide Exposure, and Pesticide Metabolism Genes

boy-outside-yard-bugs-pesticide-cancer-risk

Susan Searles Nielsen,1 Roberta McKean-Cowdin,2 Federico M. Farin,3 Elizabeth A. Holly,4 Susan Preston-Martin,2 Beth A. Mueller1,5

1Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; 2Norris Comprehensive Cancer Center/Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; 3Center for Ecogenetics and Environmental Health, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA; 4Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, California, USA; 5Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA

Environ Health Perspect 118:144-149 (2010). http://dx.doi.org/10.1289/ehp.0901226 [online 05 October 2009]


Background: Insecticides that target the nervous system may play a role in the development of childhood brain tumors (CBTs). Constitutive genetic variation affects metabolism of these chemicals.

Methods: We analyzed population-based case–control data to examine whether CBT is associated with the functional genetic polymorphisms PON1C–108T, PON1Q192R, PON1L55M, BCHEA539T, FMO1C–9536A, FMO3E158K, ALDH3A1S134A, and GSTT1 (null). DNA was obtained from newborn screening archives for 201 cases and 285 controls, ≤ 10 years of age, and born in California or Washington State between 1978 and 1990. Conception-to-diagnosis home insecticide treatment history was ascertained by interview.

Results: We observed no biologically plausible main effects for any of the metabolic polymorphisms with CBT risk. However, we observed strong interactions between genotype and insecticide exposure during childhood. Among exposed children, CBT risk increased per PON1–108T allele [odds ratio (OR) = 1.8; 95% confidence interval (CI), 1.1–3.0] and FMO1–9536A (*6) allele (OR = 2.7; 95% CI, 1.2–5.9), whereas among children never exposed, CBT risk was not increased (PON1: OR = 0.7; 95% CI, 0.5–1.0, interaction p = 0.005; FMO1: OR = 1.0; 95% CI, 0.6–1.6, interaction p = 0.009). We observed a similar but statistically nonsignificant interaction between childhood exposure and BCHEA539T (interaction p = 0.08). These interactions were present among both Hispanic and non-Hispanic white children.

Conclusion: Based on known effects of these variants, these results suggest that exposure in childhood to organophosphorus and perhaps to carbamate insecticides in combination with a reduced ability to detoxify them may be associated with CBT. Confirmation in other studies is required.

Key words: acetylcholinesterase inhibition, childhood cancer, children, gene–environment interaction, insecticides, pesticides, xenobiotic metabolism

 

View Original Article >>